publication 2: Chromium and cobalt ion release following...

Chromium and cobalt ion release following the Durom high carbon content, forged metal-on-metal surface replacement of the hip

We evaluated the concentrations of chromium and cobalt ions in blood after metal-on-metal surface replacement arthroplasty using a wrought-forged, high carbon content chromiumcobalt alloy implant in 64 patients. At one year, mean whole blood ion levels were 1.61 ?g/L (0.4 to 5.5) for chromium and 0.67 ?g/L (0.23 to 2.09) for cobalt. The pre-operative ion levels, component size, female gender and the inclination of the acetabular component were inversely proportional to the values of chromium and/or cobalt ions at one year postoperatively. Other factors, such as age and level of activity, did not correlate with the levels of metal ions. We found that the levels of the ions in the serum were 1.39 and 1.37 times higher for chromium and cobalt respectively than those in the whole blood. The levels of metal ions obtained may be specific to the hip resurfacing implant and reflect its manufacturing process.

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